The immune system has evolved to mount immune responses against foreign pathogens and to remain silent against self-antigens. A balance between immunity and tolerance is required as any disturbance ...

The immune system must be able to quickly attack invaders like viruses, while also ignoring harmless stimuli, or allergies can result. Immune cells are known to ignore or "tolerate" molecules found on ...

Dendritic cells (DCs) are among the first immune sentinels to detect viruses, bacteria, or other challenges. These specialized messengers alert T cells while orchestrating either a measured calm or a ...

Northwestern Medicine scientists in the laboratory of Stephen Miller, Ph.D., professor emeritus of Microbiology–Immunology, have identified the cellular and molecular mechanisms required for the ...

Follicular dendritic cell sarcoma (FDCS) is an uncommon neoplasm originating from the accessory cells of the immune system that ordinarily play a crucial role in antigen presentation and the ...

The immune cell repertoire is composed of many different cell types that are orchestrated in response to infection and other pathogens that enter the body. As a result, the body can defend itself ...

Clinical effectiveness of immune therapies of solid tumors requires a) the induction or expansion of T cells able of recognizing multiple variants of cancer cells present in each cancer patient, and b ...

LMU researchers have shown that a particular type of immune cell acts more flexibly than previously thought - with potential for new therapeutic approaches. As part of the innate immune system, ...

Treating the brain cancer glioblastoma (GBM) demands more than conventional strategies due to a mix of factors including the cancer’s genetic complexity, invasive growth, and immune resistance. A new ...

An international team led by researchers at Lund University in Sweden has identified the molecular tools needed to reprogram ordinary cells into specialized immune cells. The discovery, published in ...