Since it was described a half-century ago, the concept of disseminated intravascular coagulation (DIC) and its underlying pathogenesis have taken shape in accordance with the understanding of the ...

THE appearance of a severe hemorrhagic diathesis associated with the absence, or extremely low levels, of circulating fibrinogen has long been known in certain clinical conditions such as premature ...

Under homeostatic conditions, the body is maintained in a finely tuned balance of coagulation and fibrinolysis. See Figure 1 for a depiction of normal hemostasis. The activation of the coagulation ...

The clinical signs and symptoms of DIC are varied and complex. Due to the complex nature of DIC, the process often goes undetected until severe hemorrhage occurs. This is one of the reasons why DIC is ...