Background After a single-center trial and observational studies suggesting that early, goal-directed therapy (EGDT) reduced mortality from septic shock, three multicenter trials (ProCESS, ARISE, and ...

This well-conducted, preplanned, patient-level meta-analysis again demonstrates that use of EGDT in sepsis does not improve clinical outcomes compared with contemporary sepsis care where methods are ...

The investigators sought to determine whether the benefits of this guided-resuscitation strategy could be confirmed in a larger study. They randomly assigned 1341 patients from 31 EDs with severe ...