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Kidney organoids uncover Hippo signaling pathway as a therapeutic target for nephronophthisis
Using human-induced pluripotent stem cell-derived kidney organoids, researchers from Science Tokyo uncovered how abnormal Hippo signaling drives fibrosis in nephronophthisis, a genetic kidney disorder ...
CYR61, cysteine-rich angiogenic inducer 61; FT, factors of transcription; LATS, large tumor suppressor; MOB, mob kinase activator; MST, mammalian sterile 20-like ...
Obesity is one of the most prevalent and modifiable risk factors for chronic diseases such as cancer. Recent meta-analyses suggests that breast cancer-specific death among obese women is elevated ...
The field of cancer epigenetics examines how heritable changes in gene regulation - independent of DNA sequence - impact ...
Using human-induced pluripotent stem cell-derived kidney organoids, researchers from Science Tokyo uncovered how abnormal Hippo signaling drives fibrosis in nephronophthisis, a genetic kidney disorder ...
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