Isothermal Titration Calorimetry (ITC) remains the definitive technique for quantitatively assessing the thermodynamics of molecular interactions. By directly measuring heat changes during titrations, ...

All biochemical reactions involve recognition, binding, and the formation of noncovalent complexes. Many small molecule drugs act by selectively binding to protein or nucleic acid targets and altering ...

Measuring Enzyme Kinetic Parameters with the ITC Universal Enzyme Assay Method Enzymes are important in drug discovery and development since they constitute approximately one-half of all known drug ...

MicroCal has introduced the new iTC200 Isothermal Titration Calorimeter using which researchers can achieve gold standard binding affinities with only 200 µl of sample. The iTC200 determines all ...