The reaction involves adding an organolithium anion to a source of a nitrogen-containing carbon stereocenter. This chemistry builds a crucial chiral center in verubecestat, a compound Merck has ...

A flow chart, or flow diagram, is a graphical representation of a process or system that details the sequencing of steps required to create output. A typical flow chart uses a set of basic symbols to ...

Organic chemists optimizing a reaction, like chefs perfecting a dish, execute a single transformation over and over, each time tweaking a specific aspect, such as temperature or ingredient ratio, ...