Perhaps complex at first glance, in reality synNotch receptors function simply and possess unseen therapeutic potential. SynNotch is a synthetically engineered version of Notch, a receptor protein ...

The Notch signalling pathway is essential for the development and differentiation of various cell types, including immune cells. Notch ligands can promote T cell differentiation, a key step in ...

Researchers at Karolinska Institutet in Sweden have used DNA origami, the art of folding DNA into desired structures, to show how an important cell receptor can be activated in a previously unknown ...

(Nanowerk News) Researchers at Karolinska Institutet have used DNA origami, the art of folding DNA into desired structures, to show how an important cell receptor can be activated in a previously ...

The Notch signaling system links cellular fate to that of its neighbors, driving proliferation, apoptosis, and cell differentiation in metazoans, whereas dysfunction leads to debilitating ...

The Notch signaling pathway plays a pivotal role in determining cell fate, especially in the development and function of T cells. But mimicking this highly mechanical, contact-dependent pathway in the ...

In a recent study under consideration at Nature Portfolio Journal and posted to the Research Square* preprint server, researchers demonstrated the evolution of multi-system inflammatory syndrome in ...

Breast cancer (BC) remains one of the most challenging cancers to treat, primarily due to its heterogeneity and propensity for metastasis. The Notch signaling pathway is integral to various cellular ...

Abdominal pain is common in various digestive diseases, including inflammatory and irritable bowel syndrome. To develop targeted treatments for stomach discomfort, scientists uncovered a new enzyme in ...