Chemists modify protein sidechains to modulate the biomolecules’ functions. Researchers are usually stuck modifying cysteines because the amino acid’s sulfide side chain makes it the most reactive ...

The development of chemical reactions that can distinguish between the 20 common amino acids with high specificity offers the potential to decipher the sequence, structure and function of proteins.

Each protein or peptide consists of a linear sequence of amino acids. The protein primary structure conventionally begins at the amino-terminal (N) end and continues until the carboxyl-terminal (C) ...