Cytotoxic T lymphocytes (CTLs) recognize peptides from foreign antigens that are presented by major histocompatibility complex (MHC) class I molecules. Antigens are degraded in the cytosol by ...
Peptide loading of major histocompatibility complex class I (MHC-I) molecules is central to antigen presentation, self-tolerance, and CD8⁺ T-cell activation. TAP binding protein, related (TAPBPR), a ...
As task forces of the adaptive immune system, T lymphocytes are responsible for attacking and killing infected or cancerous cells. Such cells, like almost all cells in the human body, present on their ...
Tapasin (Tpn) has been implicated in multiple steps of the MHC class I assembly pathway, but the mechanisms of function remain incompletely understood. Using purified proteins, we could demonstrate ...
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