Cancer cells are pretty bold and clever—they hijack cellular survival and healing processes in order to fuel their growth, spread throughout the body, and ensure their own survival. The unfolded ...

The intestinal epithelium is a highly dynamic barrier that regulates digestion, absorption, immune responses, and communication between the gut microbiota and the nervous system. To maintain ...

Crypt-base-columnar cells are continuously dividing intestinal stem cells that generate IECs, which are composed by distinct specialised cell types that play different functions: Enterocytes (in the ...

Intestinal epithelial cells (IECs) are exposed to a challenging microenvironment that imposes high pressure on the proteostasis network. Through physiological UPR activation, IECs restore their ...