GMCL1-dependent degradation of 53BP1 suppresses mitotic surveillance, tuning p53 activation thresholds that govern cell fate decisions and cellular responses after mitosis.
Researchers from Case Western Reserve University have identified a new mechanism by which a protein known for repairing damaged DNA also protects the integrity of DNA by preserving its structural ...
Researchers have identified a new mechanism by which a protein known for repairing damaged DNA also protects the integrity of DNA by preserving its structural shape. The discovery, involving the ...
Courtesy of Linda B. Schultz CHECK POINT: The 53Bp1-dependent checkpoint pathway. DNA double-strand breaks are caused by irradiation and other geotoxic events. The ATM [ataxia-telangiectasia mutated] ...
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