It highlights the Wnt signaling pathway, emphasizing key components such as Wnt ligands, Frizzled receptors, β-catenin, and TCF/LEF, which play crucial roles in cancer progression.

Wnt proteins are highly conserved in evolution and are active in every branch of the animal kingdom. Wnt signaling is often implicated in stem cell control, as a proliferative and self-renewal signal.

The three best characterized Wnt signaling pathways are the canonical Wnt pathway, the noncanonical planar cell polarity pathway, and the noncanonical Wnt/calcium pathway.

5 days ago · WNT Legends makes its debut from 21–23 January 2026, bringing together Efren Reyes, Earl Strickland, Francisco Bustamante and Ralf Souquet for a landmark three-day showcase at …

Nov 15, 2012 · WNT receptors and co-receptors are regulated intracellularly by phosphorylation, proteolytic processing and endocytosis. Endocytosis is a key mechanism, and WNT signalling …

Jul 8, 2025 · Wnts are a vast family of secreted glycoproteins that consist of nineteen proteins, suggesting a staggering complexity in signaling regulation, function, and biological output [1]. Wnt …

Beginning with the discovery of the first mammalian Wnt gene in the early 1980’s, researchers have come to understand that Wnt signaling has an essential role in regulating many biological processes, …

The 2025 Gordon Research Conference on Wnt Signaling will be held in Lewiston, Maine. Apply today to reserve your spot.

Wnt proteins are secreted morphogens that are required for basic developmental processes, such as cell-fate specification, progenitor-cell proliferation and the control of asymmetric cell division, in many …

Oct 7, 2022 · The evolutionary-conserved Wnt proteins have been implicated in the regulation of cell proliferation and development through several different signal-transduction pathways.